منابع مشابه
Melanin pigmentation in mammalian skin and its hormonal regulation.
Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents interacting via pathways activated by receptor-dependent and -independent mechanisms, in hormonal, auto-, para-, or intracrine fashion. Because of the multidirectional nature ...
متن کاملMolecular biology of pigment cells. Molecular controls in mammalian pigmentation.
Genetic regulation in bacteria, fungi, yeast, and higher plants has been extensively studied, two well-known systems being the lactose (1) and arabinose (2) operons in Escherichia coli. The understanding of the mechanisms by which these systems function has depended heavily upon (a) the ability to obtain cells bearing mutations, thus allowing for genetic analyses of the various complementation ...
متن کاملReconciling diverse mammalian pigmentation patterns with a fundamental mathematical model
Bands of colour extending laterally from the dorsal to ventral trunk are a common feature of mouse chimeras. These stripes were originally taken as evidence of the directed dorsoventral migration of melanoblasts (the embryonic precursors of melanocytes) as they colonize the developing skin. Depigmented 'belly spots' in mice with mutations in the receptor tyrosine kinase Kit are thought to repre...
متن کاملHistochemistry of B663 Pigmentation: Ceroid-Like Pigmentation
Since its use was first reported by 8rowne and Hogerzeil in 1962 ('0. /I), 8663, a synthesized phenazine dye, has proven to be an effective drug in the treatment of human leprosy and its use has become worldwide ( 2.7.9 " . 26. 3~. 39. 52. 5.1 ). The most significant and frequent side effect of this compound is an abnormal skin coloration. This can be divided into two types. One is an initial r...
متن کاملdiverse mammalian pigmentation patterns with a fundamental mathematical 1 model 2 3
1. MRC Human Genetics Unit, MRC IGMM, Western General Hospital, University of Edinburgh, 8 EH4 2XU, UK 9 10 2. Centre for Mathematical Biology, University of Oxford, Andrew Wiles Building, Woodstock 11 Road, Oxford, OX2 6GG, UK 12 13 3. School of Dentistry, College of Medical and Dental Sciences, University of Birmingham, St. 14 Chad's, Queensway, Birmingham, B4 6NN, UK 15 16 4. Department of M...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1960
ISSN: 0022-202X
DOI: 10.1038/jid.1960.53